Interleukin-6 (IL-6)

Human IL-6 is made up of 212 amino acids, including a 28-amino-acid signal peptide. Although the core protein is 20 kDa, glycosylation accounts for the size of 21–26 kDa of natural IL-6. IL-6 can exert pro-inflammatory as well as anti-inflammatory signals, depending on the receptor complex with which it interacts. IL-6 receptor exists in membrane-bound form only on certain cell types, such as hepatocytes, neutrophils, T-cells, or monocytes.
IL-6 interacts with IL-6 receptor α and this binary complex then further binds to gp 130. The resulting complex is capable of downstream signaling. The IL-6 receptor α can function as membrane-bound proteins and exist in soluble form. Depending on the form of IL-6 receptor, IL-6 can transmit anti-inflammatory messages by binding of IL-6 to IL-6 receptor α in the cell membrane, or pro-inflammatory ones by binding to a soluble form of IL-6 receptor α.
For the development of IL-6 specific immunoassays we offer monoclonal antibodies and a recombinant human IL-6 antigen, that can be used as a calibrator in IL-6 immunoassay development.

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Interleukin 6 (IL-6) TechNotes
Cat# 4IL6: Interleukin 6 (IL-6), antibody