Canine CRP is a Marker for Systemic Inflammation

Several studies support the view that cCRP is a valuable diagnostic marker for the detection of the acute phase response in dogs. Its concentration has been shown to increase rapidly in various disorders including viral and bacterial infections, sepsis and pyometra, as well as in surgical trauma. Measuring cCRP from serum can be used in routine canine medicine (1-3 and references therein).

Canine C-reactive protein (cCRP) is a major acute phase protein in dogs.


Canine C-reactive protein (cCRP) is a major acute phase protein in dogs. Its concentration increases rapidly and significantly during systemic inflammation and subsequently decreases quickly following the elimination of the source of inflammation.

Several studies support the view that cCRP is a valuable diagnostic marker for the detection of the acute phase response in dogs. Its concentration has been shown to increase rapidly in various disorders including viral and bacterial infections, sepsis and pyometra, as well as in surgical trauma. Measuring cCRP from serum can be used in routine canine medicine (1-3 and references therein).


CRP belongs to a family of pentraxins. These evolutionally conserved proteins are pentamers and have calcium-dependent ligand binding properties. CRP is composed of five identical subunits that form a ring-like structure.

 

 

 

 

References:
1. Kjellgaard-Hansen, M. Canine C-reactive protein – a study on the applicability of canine serum C-reactive protein. Ph.D. Thesis. 2004, The Royal Veterinary and Agricultural University, Denmark.

2. Cerón J.J., Eckersall P.D. and Martýnez-Subiela S. Acute phase proteins in dogs and cats: current knowledge and future perspectives. Vet. Clin. Pathol. 2005 Jun; 34(2):85-99.

3. Eckersall P.D. and Bell R. Acute phase proteins: Biomarkers of infection and inflammation in veterinary medicine. Vet. J. 2010, 185:23-27.

Related information:
Veterinary diagnostics


Do you need samples?

We are happy to make you an offer