It looks like you're accessing our website from North America. We have a dedicated page tailored to your region, offering the most relevant information and services.
If you have an existing eCom account, you can log in to the North American site using your current username and password.
Would you like to visit the North America page?
You can access the page here
Interleukin-6 (IL-6) participates in inflammation, immune response, and acts in the coordination of developmental, neuronal, and metabolic processes. IL-6 acts as a transmitter of alarm signals to the whole organism, indicating the occurrence of an emergency such as infection or tissue damage.
For the development of
IL-6 specific immunoassays
we offer monoclonal
antibodies
and a recombinant
human IL-6 antigen, that can
be used as a calibrator
in IL-6 immunoassay development.
Human IL-6 is made up of 212 amino acids, including a 28-amino-acid signal peptide. Although the core protein is 20 kDa, glycosylation accounts for the size of 21–26 kDa of natural IL-6. IL-6 can exert pro-inflammatory as well as anti-inflammatory signals, depending on the receptor complex with which it interacts. IL-6 receptor exists in membrane-bound form only on certain cell types, such as hepatocytes, neutrophils, T-cells, or monocytes.
IL-6 interacts with IL-6 receptor α and this binary complex then further binds to gp 130. The resulting complex is capable of downstream signaling. The IL-6 receptor α can function as membrane-bound proteins and exist in soluble form. Depending on the form of IL-6 receptor, IL-6 can transmit anti-inflammatory messages by binding of IL-6 to IL-6 receptor α in the cell membrane, or pro-inflammatory ones by binding to a soluble form of IL-6 receptor α.
For the development of IL-6 specific immunoassays we offer monoclonal antibodies and a recombinant human IL-6 antigen, that can be used as a calibrator in IL-6 immunoassay development.
Learn more:
Interleukin 6 (IL-6) TechNotes
Cat# 4IL6: Interleukin 6 (IL-6), antibody