Neurofilament light (NfL) is a neuronal cytoplasmic protein that exists in axons. The concentration of NfL in cerebrospinal fluid (CSF) and blood correlate with the degree of axonal damage.
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Neurofilaments are the main cytoskeletal components in neurons, which
show their abundance in axons. Forming the core backbone of the
neurofilament, NfL is essential to the structure of the axons and it has
been found to have prognostic value.
In recent years, NfL has emerged as a biomarker for neuronal damage and other neurological conditions. Elevated NfL concentrations have been widely reported not only in CSF but also in blood under the condition of neurologic disorders, including multiple sclerosis (MS), traumatic brain injuries (TBI), and stroke.
At HyTest, we provide several monoclonal antibodies that are specific to human NfL and are designed to be used in NfL-specific immunoassays. Our antibodies do not have cross-reactivity to type III intermediate filament proteins and several other neuronal proteins.
Cat# 4NF3:Neurofilament light (NfL), human, antibody