High-sensitivity Troponin I and Troponin T

Troponin I and T are the main biomarkers and gold standards for diagnostics of acute myocardial infarction (AMI). Recently high- sensitivity cTn (hs-cTn) assays, the detection limit of which is pg/ml (ng/l) rather than ng/ml, have made it possible to identify any myocardial injury, including those AMI patients, within 1 to 3 hours. This represents a potential 3-hour time saving to ensure more rapid patient management.

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In human beings, TnI and TnT are each presented by three isoforms from which one are typical for the cardiac muscle (cTnI and cTnT). Both cTnI and cTnT are now widely used and established as the guideline recommended markers in order to assist in the diagnosis of acute myocardial infarction (AMI), as well as markers of other myocardial injuries in clinical pathologies. The current generation of commercially available hs-cTn assays are approximately 1,000 times more analytically sensitive than the first cTnI assays. The hs-cTn assays are able to detect minor cardiac injury events from a long list of pathologies that cause myocardial tissue necrosis or cell death. For the development of hs-cTn assays we offer monoclonal and polyclonal antibodies that are specific to different epitopes of both cTnI and cTnT. In addition to the antibodies, we have a recombinant cTnI, cTnT, cTn IC, and cTn ITC complex antigens that can be used a standard or calibrator in cTnI or cTnT assays. In addition, we offer TnI depleted serum to be used as matrix in the development process of the above-mentioned assays.

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Cat# 4T21/4T21cc: Troponin I (cTnI), antibody
Cat# RC4T21: Recombinant anti-cardiac troponin I (cTnI), antibody
Cat# 4TC2: Cardiac troponin complex, antibody
Cat# RC4TC2: Recombinant anti-cardiac troponin complex, antibody
Cat# 4T27cc: Troponin C (TnC), antibody
Cat# 4T19/4T19cc: Troponin T Cardiac, antibody
Cat# RC4T19: Recombinant chimeric anti-cTnT, antibody
Cat# 4T21/2: Polyclonal anti-cardiac troponin I (cTnI)

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