Serum amyloid A (SAA) is one of the major acute phase proteins in many species including cats, dogs and horses. SAA is secreted by the liver into plasma and is also produced by various extrahepatic tissues at the inflammation sites. Most circulating SAA binds to plasma high-density lipoproteins (HDL). Similarly to other acute phase reactants, SAA concentration increases in response to inflammatory stimuli. SAA as a diagnostic marker SAA is a sensitive marker of inflammation and tissue damage. In veterinary medicine, SAA measurements in blood might be used for the diagnosis of subclinical inflammation, the monitoring of treatment efficacy in animals with infections or inflammatory conditions, and the monitoring of patients who are undergoing surgery.
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