Brain natriuretic peptide (BNP) and the N-terminal part of the BNP precursor proBNP (NT-proBNP) are established diagnostic and prognostic biomarkers of heart failure (HF). HF is a severe clinical and public health problem that is characterized by an increasing prevalence and economic cost. According to the American Heart Association, its prevalence extends to 6.5 million people in the United States with nearly 1 million new cases being reported each year (1); on a global level, the prevalence reaches more than 23 million people. Chronic heart disease, hypertension and diabetes are among the known risk factors and the prevalence of HF is also higher for those people aged over 65 years. HF is associated with significant morbidity and mortality.
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